The new oncolytic virus M1 industrialization of key technologies Breakthrough
Yan light US team following the identification of an alphavirus M1 last year as a new anti-tumor oncolytic virus this year after further study found that a small molecule compound to increase production tenfold oncolytic virus replicate more than M1. This important study recently published in the field of gene and cell therapy well-known periodicals published in the US “molecular therapy” on. This will be a key step towards the industrialization of M1， will effectively expand the scope of the anti-tumor M1.
In recent years， widespread attention and in-depth study of oncolytic virus therapy， is a novel selective tumor targeting therapy. Whole animal models show that this kind of small molecule compounds can specifically increase the viral replication M1 tumors in animals， can make the novel oncolytic virus M1 yields increased more than ten times， and enhance the therapeutic effect of experimental tumors， and normal organs will not be affected. Why M1 virus will be a substantial increase in the cell？ The principle is that when M1 virus enters the cell， the cell will automatically produce many antiviral factor， while the addition of such a small molecule compound capable of activating specific signaling pathway （Epac） within the cell， so that the antiviral factor can not be “cleared” M1 virus， making M1 massive viral replication.
The clinical significance of this finding is that， on the one hand this small molecule compounds can be used as M1 virus “accelerant” M1 makes it easier to replicate in tumor cells had not sensitive， so you can expand M1 anti-tumor spectrum; another aspect， this compound may also be used as M1 virus‘ resurgence agent “oncolytic virus treatment after a period of time， again using small molecule compounds that can make a lot of re-amplification of the virus within the tumor， thereby killing many realize. This finding is more important is that these compounds will enable M1 virus easier industrial production， production costs and the future of medicine prices will be significantly reduced， marks M1 industrialization of key technologies to be broken.
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